Fármacos utilizados no tratamento do COVID-19 em pediatria

revisão integrativa

Autores

  • Kennedy Ferreira Bonifacio Hospital Materno Infantil de Brasília
  • Sarah Kelly Souza de Carvalho Faria Hospital Materno Infantil de Brasília
  • Alcidésio Sales de Souza Júnior Hospital Materno Infantil de Brasília

DOI:

https://doi.org/10.51723/ccs.v31iSuppl%201.682

Palavras-chave:

SARS-CoV-2, 2019-nCOV, COVID-19, Pediatrics

Resumo

Foi realizada uma revisão bibliográfica integrativa sobre estudos recentemente publicados entre o período de 1º de Janeiro e 24 de Abril de 2020, utilizando -se as palavras-chave: 2019-nCOV; COVID-19; SARS-CoV-2 e pediatrics. Foram pesquisados os bancos de dados PubMed, Periódicos CAPES, Science Direct, Scielo, Biblioteca Virtual em Saúde e Lilacs. Um total de 10 artigos foram considerados elegíveis. Entre as principais classes terapêuticas citadas estavam os antivirais lopinavir/ritonavir, oseltamivir, o uso do interferon e de imunoglobulinas. Quase todos os tratamentos mencionados foram considerados potencialmente eficazes contra o COVID-19, no entanto ensaios clínicos são necessários para tal confirmação visto que há poucos estudos e que o uso dos medicamentos mencionados se encontra baseado no tratamento de outras doenças respiratórias.

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Biografia do Autor

  • Kennedy Ferreira Bonifacio, Hospital Materno Infantil de Brasília

    Residente em Saúde da Criança - Escola Superior de Saúde (ESCS) – Secretaria de Estado de Saúde do Distrito Federal. Graduado em Farmácia  pela Universidade de Brasília (UnB).

  • Sarah Kelly Souza de Carvalho Faria, Hospital Materno Infantil de Brasília

    Residente em Saúde da Criança- Escola Superior de Saúde (ESCS) – Secretaria de Estado de Saúde do Distrito Federal. Graduada em Farmácia  pela Universidade de Brasília (UnB).

  • Alcidésio Sales de Souza Júnior, Hospital Materno Infantil de Brasília

    3Doutor em Desenvolvimento Inovação Tecnológica em Medicamentos pela Universidade Federal do Ceará/UFRN/UFRPE/UFPB, Preceptor do Programa de Residência Multiprofissional em Saúde da Criança, Hospital Materno Infantil de Brasília

Referências

Tezer H, Demirdağ T. Novel coronavirus disease (COVID-19) in children. Turkish Journal of Medical Sciences. 2020; 50: 592-603. https://doi.org/10.3906/sag-2004-174

Rothan H, Byrareddy S. The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak. Journal of Autoimmunity. 2020; 109: 102433. https://doi.org/10.1016/j.jaut.2020.102433

Muniyappa R, Gubbi S. COVID-19 pandemic, coronaviruses, and diabetes mellitus. American Journal of Physiology-Endocrinology and Metabolism. 2020; 318 (5): 736-741.

Centers for Disease Control and Prevention (CDC). Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020. Morbidity and Mortality Weekly Report, v.69, n. 14, 2020.

Brasil. Ministério Da Saúde. Coronavírus/Brasil. Painel Coronavírus. Disponível em: <https://covid.saude.gov.br/>. Acesso em 30 abr. 2020.

Brasil. Ministério da Saúde. Secretaria de Vigilância em Saúde. Boletim Epidemiológico. COE Nº 11, Abr. 2020. Disponível em: https://www.saude.gov.br/images/pdf/2020/April/18/2020-04-17---BE11---Boletim-do-COE-21h.pdf .

Li Y, Guo F, Cao Y, Li L, Guo Y. Insight into COVID‐2019 for pediatricians. Pediatric Pulmonology. 2020; 55 (5).

Vaduganathan M, Vardeny O, Michel T, McMurray J, Pfeffer M, Solomon S. Renin–Angiotensin–Aldosterone System Inhibitors in Patients with Covid-19. New England Journal of Medicine. 2020;382(17):1653-1659. https://doi.org/10.1056/NEJMsr2005760.

Yonker L, Shen K. Lessons unfolding from pediatric cases of COVID‐19 disease caused by SARS‐CoV‐2 infection. Pediatric Pulmonary. 2020; 55 (5): 1085-1086. https://doi.org/10.1002/ppul.24748

Calvo C, López-Hortelano M, Vicente J, Martínez J. Recommendations on the clinical management of the COVID-19 infection by the «new coronavirus» SARS-CoV2. Spanish Paediatric Association working group. Anales de Pediatría (English Edition). 2020.

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Chiotos K, Hayes M, Kimberlin D, Jones S, James S, Pinninti S et al. Multicenter Initial Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2. Journal of the Pediatric Infectious Diseases Society. 2020.

Sun D, Li H, Lu X, Xiao H, Ren J, Zhang F et al. Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study. World Journal of Pediatrics. 2020. https://doi.org/10.1007/s12519-020-00354-4

Lu Q, Shi Y. Coronavirus disease (COVID‐19) and neonate: What neonatologist need to know. Journal of Medical Virology. 2020; 92 (6):564-567.

Chen Z, Fu J, Shu Q, Chen Y, Hua C, Li F et al. Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus. World Journal of Pediatrics. 2020.

Shen K, Yang Y, Wang T, Zhao D, Jiang Y, Jin R et al. Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World Journal of Pediatrics. 2020. https://doi.org/10.1007/s12519-020-00343-7

Zimmermann P, Curtis N. Coronavirus Infections in Children Including COVID-19. The Pediatric Infectious Disease Journal. 2020;39 (5): 355-368. https://doi.org/ 10.1097/INF.0000000000002660

Rahimzadeh G, Ekrami Noghabi M, Kadkhodaei Elyaderani F, Navaeifar M, Enayati A, Manafi Anari A et al. COVID-19 Infection in Iranian Children: A Case Series of 9 Patients. Journal of Pediatrics Review. 2020:139-144.

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Cao B, Wang Y, Wen D, Liu W, Wang J, Fan G et al. A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19. New England Journal of Medicine. 2020.

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Publicado

01.06.2020

Edição

v. 31 (2020): Suplemento especial sobre a COVID-19

Seção

Fast Track : COVID-19

Licença

Declaro para os devidos fins que o artigo que estou submetendo representa um trabalho original e nunca foi publicado total ou parcialmente, e que se alguma de suas partes foi publicada possuímos autorização expressa para a publicação no periódico Comunicação em Ciências da Saúde (CCS). Esse artigo não foi enviado a outro periódico e não o será enquanto estiver sendo considerada sua publicação; caso venha a ser aceito não será publicado em outro periódico; e não contém material difamatório ou ilegal sob nenhuma forma, não viola a intimidade de terceiros, nem infringe direitos protegidos.

Eu e demais autores desse trabalho certificamos por meio desta declaração que:

  • Concordamos com as normas editoriais e com o processo de revisão da CCS;
  • Aceitamos a responsabilidade pela conduta desse estudo e pela análise e interpretação dos dados;
  • Cooperaremos, sempre que solicitado, na obtenção e fornecimento de dados sobre os quais o manuscrito está baseado, para exame dos avaliadores;
  • Não estão sendo omitidos quaisquer ligações ou acordos de financiamento entre os autores e companhias ou pessoas que possam ter interesse no material abordado no artigo;
  • Não estão sendo excluídos ou omitidos deste artigo autores ou instituições participantes;
  • Possuímos permissão para uso de figuras e tabelas publicadas em outras fontes;
  • Possuímos permissão das pessoas e instituições citadas nos agradecimentos;
  • O autor correspondente autoriza a publicação do endereço informado e e-mail do(s) autor(es) junto com o artigo;
  • Assumimos a responsabilidade pela entrega de documentos verídicos;
  • Autorizamos a publicação do referido artigo no periódico Comunicação em Ciências da Saúde, segundo critérios próprios e em número e volume a serem definidos pelo editor do periódico;
  • Nos comprometemos a atender os prazos estipulados pelos editores do periódico Comunicação em Ciências da saúde;
  • Estamos cientes de que a não manifestação no prazo de dois dias da revisão da diagramação, recebida por e-mail, será considerado aprovado para publicação.

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private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = '1c372c95cd85572e0fbc9a53d0323a0b229cfc78'; public $resource = 'frontend/pages/article.tpl'; public $type = 'app'; public $name = 'frontend/pages/article.tpl'; public $filepath = 'app:frontendpagesarticle.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7558aae9_79447201'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } } ).../smarty_internal_template.php:217
130.695023390712Smarty_Template_Resource_Base->getRenderedTemplateCode( $_template = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }]; public $parent = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = '1c372c95cd85572e0fbc9a53d0323a0b229cfc78'; public $resource = 'frontend/pages/article.tpl'; public $type = 'app'; public $name = 'frontend/pages/article.tpl'; public $filepath = 'app:frontendpagesarticle.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7558aae9_79447201'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } }, $unifunc = ??? ).../smarty_template_compiled.php:114
140.695023390712content_6740cb7558aae9_79447201( $_smarty_tpl = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }]; public $parent = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = '1c372c95cd85572e0fbc9a53d0323a0b229cfc78'; public $resource = 'frontend/pages/article.tpl'; public $type = 'app'; public $name = 'frontend/pages/article.tpl'; public $filepath = 'app:frontendpagesarticle.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7558aae9_79447201'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } } ).../smarty_template_resource_base.php:123
150.708725017952Smarty_Internal_Template->_subTemplateRender( $template = 'app:frontend/objects/article_details.tpl', $cache_id = NULL, $compile_id = '42362804174f266c598cdb32c3208fc745b92101', $caching = 0, $cache_lifetime = 3600, $data = [], $scope = 0, $forceTplCache = FALSE, $uid = ???, $content_func = ??? ).../42362804174f266c598cdb32c3208fc745b92101^1c372c95cd85572e0fbc9a53d0323a0b229cfc78_0.app.frontendpagesarticle.tpl.php:40
160.708725020376Smarty_Internal_Template->render( $no_output_filter = ???, $display = ??? ).../smarty_internal_template.php:386
170.708725020776Smarty_Template_Compiled->render( $_template = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }, 'heading' => class Smarty_Variable { ... }, 'author' => class Smarty_Variable { ... }, 'authorUserGroup' => class Smarty_Variable { ... }, 'doiObject' => class Smarty_Variable { ... }, 'doiUrl' => class Smarty_Variable { ... }, 'translatedDOI' => class Smarty_Variable { ... }, 'translatedKeywords' => class Smarty_Variable { ... }, 'keyword' => class Smarty_Variable { ... }, '__smarty_foreach_keywords' => class Smarty_Variable { ... }, 'hasBiographies' => class Smarty_Variable { ... }, 'authorName' => class Smarty_Variable { ... }, 'authorAffiliation' => class Smarty_Variable { ... }, 'parsedCitation' => class Smarty_Variable { ... }, 'pubIdPlugin' => class Smarty_Variable { ... }, 'pubId' => class Smarty_Variable { ... }, 'addThisProfileId' => class Smarty_Variable { ... }, 'addThisUsername' => class Smarty_Variable { ... }, 'addThisPassword' => class Smarty_Variable { ... }, 'addThisDisplayStyle' => class Smarty_Variable { ... }]; public $parent = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class APP\template\TemplateManager { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = 'addd65021fadf964339ab08cd1aa93ba59b14e9c'; public $resource = 'app:frontend/objects/article_details.tpl'; public $type = 'app'; public $name = 'frontend/objects/article_details.tpl'; public $filepath = 'app:frontendobjectsarticle_details.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticle_details.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7578e617_99827455'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } } ).../smarty_internal_template.php:217
180.709425171592Smarty_Template_Resource_Base->getRenderedTemplateCode( $_template = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }, 'heading' => class Smarty_Variable { ... }, 'author' => class Smarty_Variable { ... }, 'authorUserGroup' => class Smarty_Variable { ... }, 'doiObject' => class Smarty_Variable { ... }, 'doiUrl' => class Smarty_Variable { ... }, 'translatedDOI' => class Smarty_Variable { ... }, 'translatedKeywords' => class Smarty_Variable { ... }, 'keyword' => class Smarty_Variable { ... }, '__smarty_foreach_keywords' => class Smarty_Variable { ... }, 'hasBiographies' => class Smarty_Variable { ... }, 'authorName' => class Smarty_Variable { ... }, 'authorAffiliation' => class Smarty_Variable { ... }, 'parsedCitation' => class Smarty_Variable { ... }, 'pubIdPlugin' => class Smarty_Variable { ... }, 'pubId' => class Smarty_Variable { ... }, 'addThisProfileId' => class Smarty_Variable { ... }, 'addThisUsername' => class Smarty_Variable { ... }, 'addThisPassword' => class Smarty_Variable { ... }, 'addThisDisplayStyle' => class Smarty_Variable { ... }]; public $parent = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class APP\template\TemplateManager { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = 'addd65021fadf964339ab08cd1aa93ba59b14e9c'; public $resource = 'app:frontend/objects/article_details.tpl'; public $type = 'app'; public $name = 'frontend/objects/article_details.tpl'; public $filepath = 'app:frontendobjectsarticle_details.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticle_details.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7578e617_99827455'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } }, $unifunc = ??? ).../smarty_template_compiled.php:114
190.709425171592content_6740cb7578e617_99827455( $_smarty_tpl = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }, 'heading' => class Smarty_Variable { ... }, 'author' => class Smarty_Variable { ... }, 'authorUserGroup' => class Smarty_Variable { ... }, 'doiObject' => class Smarty_Variable { ... }, 'doiUrl' => class Smarty_Variable { ... }, 'translatedDOI' => class Smarty_Variable { ... }, 'translatedKeywords' => class Smarty_Variable { ... }, 'keyword' => class Smarty_Variable { ... }, '__smarty_foreach_keywords' => class Smarty_Variable { ... }, 'hasBiographies' => class Smarty_Variable { ... }, 'authorName' => class Smarty_Variable { ... }, 'authorAffiliation' => class Smarty_Variable { ... }, 'parsedCitation' => class Smarty_Variable { ... }, 'pubIdPlugin' => class Smarty_Variable { ... }, 'pubId' => class Smarty_Variable { ... }, 'addThisProfileId' => class Smarty_Variable { ... }, 'addThisUsername' => class Smarty_Variable { ... }, 'addThisPassword' => class Smarty_Variable { ... }, 'addThisDisplayStyle' => class Smarty_Variable { ... }]; public $parent = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class APP\template\TemplateManager { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = 'addd65021fadf964339ab08cd1aa93ba59b14e9c'; public $resource = 'app:frontend/objects/article_details.tpl'; public $type = 'app'; public $name = 'frontend/objects/article_details.tpl'; public $filepath = 'app:frontendobjectsarticle_details.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticle_details.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7578e617_99827455'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } } ).../smarty_template_resource_base.php:123
200.727525375256PKP\template\PKPTemplateManager->smartyCallHook( $params = ['name' => 'Templates::Article::Details'], $smarty = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = ['SCRIPT_NAME' => class Smarty_Variable { ... }, 'defaultCharset' => class Smarty_Variable { ... }, 'baseUrl' => class Smarty_Variable { ... }, 'currentContext' => class Smarty_Variable { ... }, 'currentLocale' => class Smarty_Variable { ... }, 'currentLocaleLangDir' => class Smarty_Variable { ... }, 'applicationName' => class Smarty_Variable { ... }, 'dateFormatShort' => class Smarty_Variable { ... }, 'dateFormatLong' => class Smarty_Variable { ... }, 'datetimeFormatShort' => class Smarty_Variable { ... }, 'datetimeFormatLong' => class Smarty_Variable { ... }, 'timeFormat' => class Smarty_Variable { ... }, 'displayPageHeaderTitle' => class Smarty_Variable { ... }, 'displayPageHeaderLogo' => class Smarty_Variable { ... }, 'displayPageHeaderLogoAltText' => class Smarty_Variable { ... }, 'activeTheme' => class Smarty_Variable { ... }, 'requestedPage' => class Smarty_Variable { ... }, 'requestedOp' => class Smarty_Variable { ... }, 'fbvStyles' => class Smarty_Variable { ... }, 'isUserLoggedIn' => class Smarty_Variable { ... }, 'isUserLoggedInAs' => class Smarty_Variable { ... }, 'itemsPerPage' => class Smarty_Variable { ... }, 'numPageLinks' => class Smarty_Variable { ... }, 'siteTitle' => class Smarty_Variable { ... }, 'hasSidebar' => class Smarty_Variable { ... }, 'brandImage' => class Smarty_Variable { ... }, 'sitePublicFilesDir' => class Smarty_Variable { ... }, 'publicFilesDir' => class Smarty_Variable { ... }, 'currentJournal' => class Smarty_Variable { ... }, 'primaryLocale' => class Smarty_Variable { ... }, 'supportedLocales' => class Smarty_Variable { ... }, 'enableAnnouncements' => class Smarty_Variable { ... }, 'disableUserReg' => class Smarty_Variable { ... }, 'pageFooter' => class Smarty_Variable { ... }, 'issue' => class Smarty_Variable { ... }, 'article' => class Smarty_Variable { ... }, 'publication' => class Smarty_Variable { ... }, 'currentPublication' => class Smarty_Variable { ... }, 'galley' => class Smarty_Variable { ... }, 'fileId' => class Smarty_Variable { ... }, 'submissionFileId' => class Smarty_Variable { ... }, 'userRoles' => class Smarty_Variable { ... }, 'firstPublication' => class Smarty_Variable { ... }, 'ccLicenseBadge' => class Smarty_Variable { ... }, 'section' => class Smarty_Variable { ... }, 'categories' => class Smarty_Variable { ... }, 'primaryGalleys' => class Smarty_Variable { ... }, 'supplementaryGalleys' => class Smarty_Variable { ... }, 'userGroupsById' => class Smarty_Variable { ... }, 'parsedCitations' => class Smarty_Variable { ... }, 'licenseTerms' => class Smarty_Variable { ... }, 'licenseUrl' => class Smarty_Variable { ... }, 'copyrightHolder' => class Smarty_Variable { ... }, 'copyrightYear' => class Smarty_Variable { ... }, 'pubIdPlugins' => class Smarty_Variable { ... }, 'keywords' => class Smarty_Variable { ... }, 'hasAccess' => class Smarty_Variable { ... }, 'citation' => class Smarty_Variable { ... }, 'citationArgs' => class Smarty_Variable { ... }, 'citationArgsJson' => class Smarty_Variable { ... }, 'citationStyles' => class Smarty_Variable { ... }, 'citationDownloads' => class Smarty_Variable { ... }, 'state' => class Smarty_Variable { ... }, 'heading' => class Smarty_Variable { ... }, 'author' => class Smarty_Variable { ... }, 'authorUserGroup' => class Smarty_Variable { ... }, 'doiObject' => class Smarty_Variable { ... }, 'doiUrl' => class Smarty_Variable { ... }, 'translatedDOI' => class Smarty_Variable { ... }, 'translatedKeywords' => class Smarty_Variable { ... }, 'keyword' => class Smarty_Variable { ... }, '__smarty_foreach_keywords' => class Smarty_Variable { ... }, 'hasBiographies' => class Smarty_Variable { ... }, 'authorName' => class Smarty_Variable { ... }, 'authorAffiliation' => class Smarty_Variable { ... }, 'parsedCitation' => class Smarty_Variable { ... }, 'pubIdPlugin' => class Smarty_Variable { ... }, 'pubId' => class Smarty_Variable { ... }, 'addThisProfileId' => class Smarty_Variable { ... }, 'addThisUsername' => class Smarty_Variable { ... }, 'addThisPassword' => class Smarty_Variable { ... }, 'addThisDisplayStyle' => class Smarty_Variable { ... }]; public $parent = class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class APP\template\TemplateManager { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'frontend/pages/article.tpl'; public $mustCompile = FALSE; public $templateId = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/#app:frontend/pages/article.tpl##42362804174f266c598cdb32c3208fc745b92101#0'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }; public $config_vars = []; public $ext = class Smarty_Internal_Extension_Handler { public $objType = 2; private $_property_info = [...]; private $resolvedProperties = [...]; public $getTemplateVars = class Smarty_Internal_Method_GetTemplateVars { ... } }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = []; public $_cache = []; public $smarty = class APP\template\TemplateManager { public $_objType = 1; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = NULL; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = NULL; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $auto_literal = TRUE; public $error_unassigned = FALSE; public $use_include_path = FALSE; public $_templateDirNormalized = TRUE; public $_joined_template_dir = '/var/www/html/templates/#/var/www/html/plugins/themes/default/templates/'; public $_configDirNormalized = FALSE; public $_joined_config_dir = NULL; public $default_template_handler_func = NULL; public $default_config_handler_func = NULL; public $default_plugin_handler_func = NULL; public $_compileDirNormalized = TRUE; public $_pluginsDirNormalized = FALSE; public $_cacheDirNormalized = FALSE; public $force_compile = FALSE; public $use_sub_dirs = FALSE; public $allow_ambiguous_resources = FALSE; public $merge_compiled_includes = FALSE; public $extends_recursion = TRUE; public $force_cache = FALSE; public $left_delimiter = '{'; public $right_delimiter = '}'; public $literals = [...]; public $security_class = 'Smarty_Security'; public $security_policy = NULL; public $allow_php_templates = FALSE; public $debugging = FALSE; public $debugging_ctrl = 'NONE'; public $smarty_debug_id = 'SMARTY_DEBUG'; public $debug_tpl = NULL; public $error_reporting = 32757; public $config_overwrite = TRUE; public $config_booleanize = TRUE; public $config_read_hidden = FALSE; public $compile_locking = TRUE; public $cache_locking = FALSE; public $locking_timeout = 10; public $default_resource_type = 'app'; public $caching_type = 'file'; public $default_config_type = 'file'; public $cache_modified_check = FALSE; public $registered_plugins = [...]; public $registered_objects = [...]; public $registered_classes = [...]; public $registered_filters = [...]; public $registered_resources = [...]; public $registered_cache_resources = [...]; public $autoload_filters = [...]; public $default_modifiers = [...]; public $escape_html = FALSE; public $start_time = 1732522126.8367; public $_current_file = NULL; public $_parserdebug = FALSE; public $_debug = NULL; protected $template_dir = [...]; protected $_processedTemplateDir = [...]; protected $config_dir = '/var/www/html/cache/t_config'; protected $_processedConfigDir = [...]; protected $compile_dir = '/var/www/html/cache/t_compile/'; protected $plugins_dir = [...]; protected $cache_dir = '/var/www/html/cache/t_cache'; protected $obsoleteProperties = [...]; protected $accessMap = [...]; private ${Smarty}isMutingUndefinedOrNullWarnings = FALSE; private ${PKP\template\PKPTemplateManager}_styleSheets = [...]; private ${PKP\template\PKPTemplateManager}_javaScripts = [...]; private ${PKP\template\PKPTemplateManager}_htmlHeaders = [...]; private ${PKP\template\PKPTemplateManager}_constants = [...]; private ${PKP\template\PKPTemplateManager}_localeKeys = [...]; protected $_state = [...]; private ${PKP\template\PKPTemplateManager}_cacheability = 'no-store'; private ${PKP\template\PKPTemplateManager}_fbv = class PKP\form\FormBuilderVocabulary { ... }; private ${PKP\template\PKPTemplateManager}_request = class APP\core\Request { ... }; private array ${PKP\template\PKPTemplateManager}headers = [...]; private bool ${PKP\template\PKPTemplateManager}isBackendPage = FALSE }; public $source = class Smarty_Template_Source { public $uid = 'addd65021fadf964339ab08cd1aa93ba59b14e9c'; public $resource = 'app:frontend/objects/article_details.tpl'; public $type = 'app'; public $name = 'frontend/objects/article_details.tpl'; public $filepath = 'app:frontendobjectsarticle_details.tpl'; public $timestamp = 1724439197; public $exists = TRUE; public $basename = NULL; public $components = NULL; public $handler = class PKP\template\PKPTemplateResource { ... }; public $smarty = class APP\template\TemplateManager { ... }; public $isConfig = FALSE; public $content = NULL; public $compiler_class = 'Smarty_Internal_SmartyTemplateCompiler'; public $template_lexer_class = 'Smarty_Internal_Templatelexer'; public $template_parser_class = 'Smarty_Internal_Templateparser' }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = []; public $endRenderCallbacks = []; public $compiled = class Smarty_Template_Compiled { public $filepath = '/var/www/html/cache/t_compile/42362804174f266c598cdb32c3208fc745b92101^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticle_details.tpl.php'; public $timestamp = 1732299637; public $exists = TRUE; public $compile_id = NULL; public $processed = TRUE; public $unifunc = 'content_6740cb7578e617_99827455'; public $has_nocache_code = FALSE; public $file_dependency = [...]; public $content = NULL; public $includes = [...]; public $isCache = FALSE; public $nocache_hash = NULL } } ).../42362804174f266c598cdb32c3208fc745b92101^addd65021fadf964339ab08cd1aa93ba59b14e9c_0.app.frontendobjectsarticle_details.tpl.php:560
210.727525375696PKP\plugins\Hook::call( $hookName = 'Templates::Article::Details', $args = [0 => ['name' => 'Templates::Article::Details'], 1 => class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class Smarty_Internal_Template { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }, 2 => '\t<div class="item citation">\n\t\t<section class="sub_item citation_display">\n\t\t\t<h2 class="label">\n\t\t\t\tComo Citar\n\t\t\t</h2>\n\t\t\t<div class="value">\n\t\t\t\t<div id="citationOutput" role="region" aria-live="polite">\n\t\t\t\t\t<div class="csl-bib-body">\n <div class="csl-entry"><div class="csl-left-margin">1.</div><div class="csl-right-inline">Fármacos utilizados no tratamento do COVID-19 em pediatria : revisão integrativa. Com. Ciências Saúde [Internet]. 1º de junho de 2020 [citado 25º de novembro de 2024];31(Suppl'...] ).../PKPTemplateManager.php:1784
220.727525376072PKP\plugins\Hook::run( $hookName = 'Templates::Article::Details', $args = [0 => [0 => [...], 1 => class Smarty_Internal_Template { ... }, 2 => '\t<div class="item citation">\n\t\t<section class="sub_item citation_display">\n\t\t\t<h2 class="label">\n\t\t\t\tComo Citar\n\t\t\t</h2>\n\t\t\t<div class="value">\n\t\t\t\t<div id="citationOutput" role="region" aria-live="polite">\n\t\t\t\t\t<div class="csl-bib-body">\n <div class="csl-entry"><div class="csl-left-margin">1.</div><div class="csl-right-inline">Fármacos utilizados no tratamento do COVID-19 em pediatria : revisão integrativa. Com. Ciências Saúde [Internet]. 1º de junho de 2020 [citado 25º de novembro de 2024];31(Suppl'...]] ).../Hook.php:113
230.728225425112call_user_func_array:{/var/www/html/lib/pkp/classes/plugins/Hook.php:139}( $callback = [0 => class APP\plugins\generic\citations\CitationsPlugin { public $pluginPath = 'plugins/generic/citations'; public $pluginCategory = 'generic'; public $request = NULL }, 1 => 'citationsContent'], $args = [0 => 'Templates::Article::Details', 1 => [0 => [...], 1 => class Smarty_Internal_Template { ... }, 2 => '\t<div class="item citation">\n\t\t<section class="sub_item citation_display">\n\t\t\t<h2 class="label">\n\t\t\t\tComo Citar\n\t\t\t</h2>\n\t\t\t<div class="value">\n\t\t\t\t<div id="citationOutput" role="region" aria-live="polite">\n\t\t\t\t\t<div class="csl-bib-body">\n <div class="csl-entry"><div class="csl-left-margin">1.</div><div class="csl-right-inline">Fármacos utilizados no tratamento do COVID-19 em pediatria : revisão integrativa. Com. Ciências Saúde [Internet]. 1º de junho de 2020 [citado 25º de novembro de 2024];31(Suppl'...]] ).../Hook.php:139
240.728225425440APP\plugins\generic\citations\CitationsPlugin->citationsContent( $hookName = 'Templates::Article::Details', $args = [0 => ['name' => 'Templates::Article::Details'], 1 => class Smarty_Internal_Template { public $_objType = 2; public $template_class = 'Smarty_Internal_Template'; public $tpl_vars = [...]; public $parent = class Smarty_Internal_Template { ... }; public $config_vars = [...]; public $ext = class Smarty_Internal_Extension_Handler { ... }; public $cache_id = NULL; public $compile_id = '42362804174f266c598cdb32c3208fc745b92101'; public $caching = 0; public $compile_check = 1; public $cache_lifetime = 3600; public $tplFunctions = [...]; public $_cache = [...]; public $smarty = class APP\template\TemplateManager { ... }; public $source = class Smarty_Template_Source { ... }; public $inheritance = NULL; public $template_resource = 'app:frontend/objects/article_details.tpl'; public $mustCompile = FALSE; public $templateId = '36060c7c43ad1691e04870da0cec54c0d1263666'; public $scope = 0; public $isRenderingCache = FALSE; public $startRenderCallbacks = [...]; public $endRenderCallbacks = [...]; public $compiled = class Smarty_Template_Compiled { ... } }, 2 => '\t<div class="item citation">\n\t\t<section class="sub_item citation_display">\n\t\t\t<h2 class="label">\n\t\t\t\tComo Citar\n\t\t\t</h2>\n\t\t\t<div class="value">\n\t\t\t\t<div id="citationOutput" role="region" aria-live="polite">\n\t\t\t\t\t<div class="csl-bib-body">\n <div class="csl-entry"><div class="csl-left-margin">1.</div><div class="csl-right-inline">Fármacos utilizados no tratamento do COVID-19 em pediatria : revisão integrativa. Com. Ciências Saúde [Internet]. 1º de junho de 2020 [citado 25º de novembro de 2024];31(Suppl'...] ).../Hook.php:139
250.728225426280json_decode( $json = NULL, $associative = TRUE ).../CitationsPlugin.php:68

Como Citar

1.
Fármacos utilizados no tratamento do COVID-19 em pediatria : revisão integrativa. Com. Ciências Saúde [Internet]. 1º de junho de 2020 [citado 25º de novembro de 2024];31(Suppl1):94-104. Disponível em: https://revistaccs.espdf.fepecs.edu.br/index.php/comunicacaoemcienciasdasaude/article/view/682

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